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Alaska Blind Child Discovery

A cooperative, charitable research project to vision screen every preschool Alaskan

Amblyopia Treatment Studies

Dr. Arnold and Diane Armitage did enroll patients in NIH-sponsored clinical trials of amblyopia treatment as Pediatric Eye Disease Investigator Group (PEDIG) Site #04.
ABCD History
PEDIG at JAEB Website
An Alaska ATS patient randomizes himself over the Internet with PEDIG:
Kids Eye Disorders
Amblyopia Treatment Study = ATS        
ATS-1 Atropine vs part-time patch: moderate amblyopia    
Vision Screening
ATS-2A Patch 6 hrs vs full-time: severe amblyopia

To enroll in an ATS trial, children must be diagnosed with amblyopia and NOT have had recent amblyopia therapy. They must have a recent cycloplegic refraction and proper spectacle trial. Each must undergo a standardized acuity test using EVA (surround HOTV or ETDRS) protocol. ALL ATS acuity measurements must be done with the non-tested eye patched. Parents are then offered the option to enroll their amblyopic child into a treatment phase which randomizes the child to one of two accepted doses of treatment; either some form of patching or atropine penalization of the better eye.

ATS-2B Patch 2 hrs vs 6 hours: moderate amblyopia
ABCD Clinics
ATS-2C Spectacles but stop patch/atropine after success 1 year
ATS-3 Teens: spectacles vs atropine/patch
Contact ABCD
ATS-4 Atropine: weekend vs daily; moderate amblyopia
ATS-5 Spectacles alone, then patch 2 hrs vs spectacles
ATS-6 Patch 2 hours with near vs far activities after specs
PEDIG papers
ATS-7 Bilateral refractive amblyopia; spectacles x 1 year    
ATS-8 Atropine: full specs vs reduced plus
ETS-1 observation of recent-onset esotropia / surgery
ATS-9 Teen "ATS-1": weekend atropine vs patch 2 hrs
NLD-1-3 compared surgical treatment of tear duct obstruction


ATS-11 terminated

ATS-12 terminated

ATS-13 current





Bangerter filters for amblyopia

Final Ramp-up for residual amblyopia

Vision Therapy Pilot Study

Spectacles for Strabismic Amblyopia

Levodopa Pilot Study

Increasing Patching for Amblyopia

Augmenting Atropine Treatment for Amblyopia

Levodopa for Residual Amblyopia

X01 spectacles for new amblyopic patients

Corneal Thickness

NLD-2: stent vs balloon for recurrent NLD

NLD-3: office now vs OR probe later NLD

IXT-1: BLR vs R&R for intermittent exotropia


Review in AAP "Pediatrics" 2013

PEDIG is a collaborative group of academic optometrists, orthoptists and ophthalmologists combined with community pediatric ophthalmologists including Dr. Arnold. PEDIG is located in the JAEB Center in Tampa, Florida and is chaired by Roy Beck, MD, PhD. PEDIG enjoys generous NIH support due to efficient recruitment and care of common pediatric eye disorders such as amblyopia (strabismic and refractive), esotropia and nasolacrimal duct obstruction. In part due to successful screening by ABCD, many young Alaskans have participated in Amblyopia Treatment Study and Esotropia Treatment Study Trials.      
Active PEDIG recruiting Investigators: Robert Arnold, Jonathan Holmes, Mike Repka, Nick Sala, David Silbert and Darren Hoover. Dr.s Holmes and Repka oversee PEDIG with Dr. Roy Beck.

Devoted Leaders of PEDIG and the JAEB Center: Don Evertt (NIH), Roy Beck (JAEB), Jonathan Holmes (Mayo), Ray Kraker (PEDIG), Mike Repka (Johns Hopkins)



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